Health Library

 

Thrombolytic Medicines for Pulmonary Embolism

Topic Overview

Thrombolytic medicines, such as streptokinase or tissue-type plasminogen activator (t-PA), interfere with the action of thrombin, which is needed to form blood clots. These medicines help to dissolve blood clots and may be used to treat pulmonary embolism in life-threatening situations.

All thrombolytics can cause serious bleeding. Bleeding inside the brain is a particular danger that can cause a stroke or death. In general, thrombolytics are used only where the risk of bleeding can be balanced against the risks of not dissolving the blood clot rapidly. Thrombolytics might be used when you have a large blood clot that is:

  • Severely blocking blood flow.
  • Decreasing the heart's ability to pump blood.
  • Causing very low blood pressure and shock.

These medicines are given through a vein in the hand or arm. Sometimes it is necessary to insert a catheter and give the medicine directly into the pulmonary artery. You must be hospitalized to receive thrombolytic medicines.

Related Information

References

Other Works Consulted

  • Guyatt GH, et al. (2012). Executive summary: Antithrombotic therapy and prevention of thrombosis, 9th ed.—American College of Chest Physicians evidence-based clinical practice guidelines. Chest, 141(2, Suppl): 7S–47S.
  • Weitz JI (2012). Pulmonary embolism. In L Goldman, A Shafer, eds., Goldman's Cecil Medicine, 24th ed., pp. 596–603. Philadelphia: Saunders.

Credits

By Healthwise Staff
Primary Medical Reviewer E. Gregory Thompson, MD - Internal Medicine
Specialist Medical Reviewer Jeffrey S. Ginsberg, MD - Hematology
Last Revised January 10, 2013

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

© 1995-2013 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

First Nurse

First Nurse

Call First Nurse 24 Hours a Day for free health care advice, resources and referrals!

Ames: 515-239-6877
In Iowa: 800-524-6877 

Search health information online in our Mulimedia Health Library.

High Quality Care

Guardian of Excellence

Mary Greeley consistently delivers high quality patient care.

  • 2013 Guardian of Excellence Award for Clinical Quality
  • Grade 'A' Patient Safety from the Leapfrog Group
  • 2013 Top Performer on Key Quality Measures ranking from The Joint Commission
  • Highest percentage bonus of any Iowa hospital in Medicare's quality incentive program

Mary Greeley on Facebook

Like us on Facebook

Patient Privacy | Net Learning for Employees | MGMC PACS for Physicians
Emergency Preparedness

1111 Duff Avenue Ames, IA 50010 - 515-239-2011 - yourhealth.mgmc@mgmc.com

©2014 Mary Greeley Medical Center - All rights reserved.