Home > Health & Wellness > Health Library > Combination Drug Therapy for Peptic Ulcer Disease
therapy regimens commonly used to treat an H. pylori
infection include the following options:
Some examples of antibiotics used
to treat H. pylori are:
Some of the recommended drug combinations are
packaged together for convenience.
The right antibiotics combinations
Helicobacter pylori (H. pylori) bacteria that are the cause of many peptic ulcers.
At least two antibiotics are used, because combination treatment works better and is less
likely to fail because of
resistance to the antibiotics.
Combination drug therapy that
includes at least two antibiotics, an acid reducer, and sometimes a bismuth
compound is recommended for people who have peptic ulcer disease and are known
to be infected with Helicobacter pylori (H. pylori).
Helicobacter pylori (H. pylori) infections are cured 70% to 85% of the time when the right combination drug treatment is used.1
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
Call 911 or other emergency services right away if you have:
Call your doctor if you have:
Common side effects of this medicine include:
Drug Reference for a full list of side effects. (Drug Reference is not
available in all systems.)
It is very important that you
take all of the medicine prescribed. Do not stop taking your medicine even if
you feel better. It may seem like a lot of pills to take, but it is also
important to take a regimen that contains at least three medicines to cure
Helicobacter pylori (H. pylori).
Combination regimens are the most effective way to help ensure that
H. pylori bacteria do not develop resistance to the
antibiotics used to treat them.
Completely avoid alcohol use (including nonprescription nighttime cold medicines, such as NyQuil) when you are taking metronidazole. Combining alcohol with this medicine may cause severe nausea and vomiting.
Tetracycline can make your skin more sensitive to the sun.
Avoid taking milk and other dairy products, antacids, or supplements and vitamins containing iron within 2 hours of taking tetracycline.
Taking these medicines with a full glass of water can help prevent irritation of the esophagus.
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
Do not use this medicine if you are pregnant or planning to get pregnant. If you need to use this medicine, talk to your doctor about how you can prevent pregnancy.
If you are pregnant, breast-feeding, or planning to get pregnant, do not use any medicines unless your doctor tells you to. Some medicines can harm your baby. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. And make sure that all your doctors know that you are pregnant, breast-feeding, or planning to get pregnant.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
Some people who
have been treated for H. pylori infection need
follow-up testing to ensure that the infection is
Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
Chey WD, et al. (2007). American College of
Gastroenterology guideline of the management of Helicobacter pylori infection. American Journal of Gastroenterology, 102(8): 1808–1825.
Other Works Consulted
Yang YX, et al. (2006). Long-term proton pump
inhibitor therapy and risk of hip fracture. JAMA,
Current as of:
November 15, 2013
E. Gregory Thompson, MD - Internal Medicine & Jerome B. Simon, MD, FRCPC, FACP - Gastroenterology
How this information was developed to help you make better health decisions.
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