Health Library

 

Chronic Fatigue: Antidepressants

Topic Overview

Antidepressants do not cure CFS. They may relieve symptoms such as fatigue, sleep problems, difficulty concentrating, and pain. But they will not affect the course of the illness or the speed of recovery.

Antidepressants that are commonly used to treat chronic fatigue syndrome (CFS) include:

  • Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine (for example, Prozac), paroxetine (Paxil), sertraline (Zoloft), citalopram (Celexa), and escitalopram (Lexapro).
  • Tricyclic antidepressants, such as amitriptyline, desipramine (Norpramin), imipramine (Tofranil), and nortriptyline (Pamelor).
  • Other antidepressants, such as bupropion (Wellbutrin), trazodone, venlafaxine (Effexor), and mirtazapine (Remeron).

When these medicines are used to treat CFS, they may be given in lower doses than the amounts used to treat depression.

The choice of medicine may depend on the symptoms that are most bothersome, because each medicine has somewhat different side effects. For example:

  • If you have trouble sleeping, you may need a medicine to take at bedtime that causes drowsiness.
  • If you have trouble concentrating on daily tasks, you may need a medicine to take during the day that can help with concentration and clear thinking.

If depression has been diagnosed along with CFS, antidepressants may be used to treat depression also.

The U.S. Food and Drug Administration (FDA) has issued an advisory on antidepressant medicines and the risk of suicide. Talk with your doctor about these possible side effects and the warning signs of suicide.

Do not suddenly stop taking antidepressants. These medicines must be gradually tapered off under your doctor's supervision.

Related Information

Credits

By Healthwise Staff
Primary Medical Reviewer Anne C. Poinier, MD - Internal Medicine
Specialist Medical Reviewer Nancy Greenwald, MD - Physical Medicine and Rehabilitation
Current as of March 12, 2014

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

© 1995-2014 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

First Nurse

First Nurse

Call First Nurse 24 Hours a Day for free health care advice, resources and referrals!

Ames: 515-239-6877
In Iowa: 800-524-6877 

Search health information online in our Mulimedia Health Library.

Symptom Checker

Use our interactive symptom checker to evaluate your symptoms and determine appropriate action or treatment.

Symptom Checker

Patient Privacy | Net Learning for Employees | MGMC PACS for Physicians
Emergency Preparedness

1111 Duff Avenue Ames, IA 50010 - 515-239-2011 - yourhealth.mgmc@mgmc.com

©2014 Mary Greeley Medical Center - All rights reserved.