Health Library

 

Medicines for Erection Problems: Reactions With Nitrate

Topic Overview

Phosphodiesterase-5 inhibitors, such as sildenafil (for example, Viagra), have made a big difference in the treatment of erection problems (erectile dysfunction). But they can cause life-threatening side effects for anyone who also takes nitroglycerin or another medicine containing an organic nitrate. This combination can make your blood pressure fall too low. This can possibly cause a stroke, a heart attack, or death. Do not take nitrate medicines up to 24 hours after you take sildenafil (for example, Viagra) or vardenafil (for example, Levitra). Do not take nitrate medicines up to 48 hours after you take tadalafil (for example, Cialis).

Medicines that contain organic nitrates include:

  • Nitroglycerin (such as Nitro-Dur, Nitrolingual, Nitrostat).
  • Isosorbide (such as Dilatrate, Isordil).
  • Nitroprusside (such as Nitropress).
  • Amyl nitrite or amyl nitrate. These are sometimes called "poppers." They are sometimes abused.

Nitrates found in foods are not a danger when taking phosphodiesterase-5 inhibitors.

References

Other Works Consulted

  • Levine GN, et al. (2012). Sexual activity and cardiovascular disease: A scientific statement from the American Heart Association. Circulation, 125(8): 1058–1072.

Credits

By Healthwise Staff
Primary Medical Reviewer E. Gregory Thompson, MD - Internal Medicine
Specialist Medical Reviewer Christopher G. Wood, MD, FACS - Urology, Oncology
Current as of June 4, 2014

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

© 1995-2014 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

First Nurse

First Nurse

Call First Nurse 24 Hours a Day for free health care advice, resources and referrals!

Ames: 515-239-6877
In Iowa: 800-524-6877 

Search health information online in our Mulimedia Health Library.

Symptom Checker

Use our interactive symptom checker to evaluate your symptoms and determine appropriate action or treatment.

Symptom Checker

Patient Privacy | Net Learning for Employees | MGMC PACS for Physicians
Emergency Preparedness

1111 Duff Avenue Ames, IA 50010 - 515-239-2011 - yourhealth.mgmc@mgmc.com

©2014 Mary Greeley Medical Center - All rights reserved.