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Clinical Trials for Multiple Sclerosis Treatment

During clinical trials, people who have multiple sclerosis (MS) participate in studies that test new therapies for the disease. The therapies tested in clinical trials have shown promise in laboratory and animal research, but they may not have been shown to be safe and effective for humans yet. Each trial requires that a person meet specific requirements (involving, for example, age, time since diagnosis, and course of MS) in order to ensure that the results will be clear enough to be useful.

Medicines being tested in clinical trials pass through four phases:

  • Phase I: Testing for safety
  • Phase II: Testing for effectiveness against the disease. This phase is usually limited to less than 50 people.
  • Phase III: Comparing the medicine with a placebo or an already approved therapy. Participants are watched closely for side effects. This phase may involve hundreds of people in several locations.
  • Phase IV: Further testing of approved medicines

Call the National Multiple Sclerosis Society (1-800-FIGHT-MS, or 1-800-344-4867) or the Brain Resources and Information Network of the National Institute of Neurological Disorders and Stroke (1-800-352-9424) for information on clinical trials. Or visit the National Institutes of Health clinical trials website at www.ClinicalTrials.gov. Discuss with your doctor, nurse, or therapist the possibility of participating in a trial. Current clinical trials involve testing new medicines, higher doses of existing medicines, and combination therapies.

By Healthwise Staff
Primary Medical Reviewer Adam Husney, MD - Family Medicine
Primary Medical Reviewer Anne C. Poinier, MD - Internal Medicine
Specialist Medical Reviewer Barrie J. Hurwitz, MD - Neurology
Current as of March 12, 2014

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