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  • vemurafenib
 

vemurafenib

Pronunciation: VEM ue RAF e nib

Brand: Zelboraf

What is the most important information I should know about vemurafenib?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Many drugs can interact with vemurafenib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is vemurafenib?

Vemurafenib is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Vemurafenib is used to treat metastatic melanoma (skin cancer).

Vemurafenib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking vemurafenib?

Multum donot

You should not use vemurafenib if you are allergic to it.

To make sure you can safely use vemurafenib, tell your doctor if you have any of these other conditions:

  • liver disease;
  • a heart rhythm disorder;
  • a personal or family history of Long QT syndrome;
  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or
  • if you take any other medicines, including antibiotics, antidepressants, heart rhythm medication, or medicine to treat mental illness.
Multum emt

Using vemurafenib may increase your risk of developing other types of skin cancer. Report any new or worsening skin lesions to your doctor right away.

Multum nopreg

FDA pregnancy category D. Do not use vemurafenib if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Multum nobrfeed

It is not known whether vemurafenib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using vemurafenib.

How should I take vemurafenib?

Before you start treatment, your doctor may perform tests to make sure vemurafenib is the best treatment for your type of skin cancer.

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Multum water

Take this medicine with a full glass of water. You may take vemurafenib with or without food.

Take the medicine every 12 hours, at the same time each day.

Multum nocrush

Do not crush, chew, or break a vemurafenib tablet. Swallow it whole.

While using vemurafenib, you may need frequent blood tests to check your liver function.

Multum emt

To make sure this medication is not causing harmful effects, your skin condition will need to be checked often. Your heart function may also need to be tested with an electrocardiogram (ECG or EKG) on a regular basis. You may also need eye exams. Your cancer treatments may be delayed based on the results of these tests.

Your doctor may want to check your skin for several months after you stop using vemurafenib. Visit your doctor regularly.

Multum rt

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 4 hours away. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking vemurafenib?

Multum nosun

Avoid exposure to sunlight or tanning beds. Vemurafenib can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of vemurafenib?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum calldoc

Stop using vemurafenib and call your doctor at once if you have:

  • new or worsening skin lesions;
  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
  • vision changes;
  • eye pain or redness, puffy eyes;
  • white patches on your eyes;
  • liver problems --nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • severe skin reaction --fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • joint pain;
  • tired feeling;
  • nausea;
  • hair loss;
  • mild rash or itching;
  • skin growths; or
  • blurred vision, increased sensitivity of your eyes to light.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect vemurafenib?

Many drugs can interact with vemurafenib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about vemurafenib.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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