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penicillin G sodium

Pronunciation: PEN i SIL in G SOE dee um

What is the most important information I should know about penicillin G sodium?

Multum donot

You should not use this medication if you are allergic to penicillin. Tell your doctor if you have ever had an allergic reaction to a cephalosporin antibiotic such as Ceftin, Cefzil, Omnicef, Keflex, and others.

Before using penicillin G sodium, tell your doctor if you have asthma or a history of allergies, liver disease, kidney disease, or heart disease.

Multum emt

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Penicillin G sodium will not treat a viral infection such as the common cold or flu.

After you have finished your treatment with penicillin G sodium, your doctor may want to do tests to make sure your infection has completely cleared up.

What is penicillin G sodium?

Penicillin G sodium is a fast-acting antibiotic that fights bacteria in your body.

Penicillin G sodium is used to treat many different types of severe infections, including strep infections, meningitis, anthrax, pneumonia, gonorrhea, and syphilis.

Penicillin G sodium may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using penicillin G sodium?

Multum donot

You should not use this medication if you are allergic to penicillin. Tell your doctor if you have ever had an allergic reaction to a cephalosporin antibiotic such as cefdinir (Omnicef), cefprozil (Cefzil), cefuroxime (Ceftin), cephalexin (Keflex), and others.

To make sure you can safely use penicillin G sodium, tell your doctor if you have any of these other conditions:

  • asthma or a history of allergies;
  • liver disease;
  • kidney disease; or
  • heart disease.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Multum nobrfeed

Penicillin G sodium can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is penicillin G sodium given?

Penicillin G sodium is injected into a muscle or into a vein through an IV. You may be shown how to use an injection at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Penicillin G sodium is a powder medicine that must be mixed with a liquid (diluent) before using it. Shake the mixture well before you measure a dose. If you are using the injections at home, be sure you understand how to properly mix and store the medication.

Prepare your dose in a syringe only when you are ready to give yourself an injection. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.

Multum emt

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Penicillin G sodium will not treat a viral infection such as the common cold or flu.

If you use this medication long-term, your blood may need to be tested to make sure the medicine is not causing harmful effects. Your kidney or liver function may also need to be tested. Visit your doctor regularly.

This medication can cause false results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using penicillin G sodium.

After you have finished your treatment with penicillin G sodium, your doctor may want to do tests to make sure your infection has completely cleared up.

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Store unmixed medicine at room temperature away from moisture and heat.

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After mixing penicillin G sodium with a diluent, store in the refrigerator and use it within 3 days. Do not freeze.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your penicillin G sodium injection.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include confusion, agitation, hallucinations, or seizure (convulsions).

What should I avoid while taking penicillin G sodium?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking this medication and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

What are the possible side effects of penicillin G sodium?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody;
  • blood in your urine;
  • feeling like you might pass out;
  • fever, chills, swollen glands, body aches, flu symptoms, rash or itching, muscle or joint pain, night sweats, general ill feeling;
  • white patches or sores inside your mouth or on your lips;
  • urinating less than usual or not at all;
  • skin rash with bruising, severe tingling, numbness, pain, muscle weakness;
  • swelling in your hands or feet;
  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • twitching or uncontrollable muscle movements; or
  • increased thirst, feeling restless, increased urination, muscle pain or weakness, irregular heart rate, weak pulse, tingly feeling, feeling light-headed, fainting, or seizure (convulsions).

Less serious side effects may include:

  • pain, swelling, bruising, or irritation around the IV needle;
  • overactive reflexes;
  • nausea, vomiting; or
  • black or hairy tongue.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect penicillin G sodium?

Tell your doctor about all other medications you use, especially:

  • aspirin or indomethacin (Indocin);
  • birth control pills;
  • methotrexate (Rheumatrexate, Trexall);
  • probenecid (Benemid);
  • an antibiotic such as chloramphenicol (Chloromycetin) or erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin);
  • a diuretic (water pill) such as furosemide (Lasix) or ethacrynic acid (Edecrin);
  • sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others); or
  • a tetracycline antibiotic, such as doxycycline (Doryx, Oracea, Periostat, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

This list is not complete and other drugs may interact with penicillin G sodium. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about penicillin G sodium.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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