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  • collagenase clostridium histolyticum
 

collagenase clostridium histolyticum

Pronunciation: KOL a JEN ase klos TRID ee um HIS toe LIT ik um

Brand: Xiaflex

What is the most important information I should know about collagenase clostridium histolyticum?

Before you receive this medication, tell your doctor if you have a bleeding or blood clotting disorder, such as hemophilia.

The day after your injection, your doctor will need to examine your hand to see if your condition has improved. Avoid any strenuous activity using the treated hand until your doctor tells you to resume normal activities.

Multum donot

Tell your caregiver at once if you have a serious side effect in the treated hand, such as bruising, bleeding, swelling, redness, warmth, numbness, tingling, or sudden pain or loss of movement.

Multum emt

Call your doctor if you have fever, chills, body aches, flu symptoms, or swollen glands in your elbow or underarm.

What is collagenase clostridium histolyticum?

Collagenase clostridium histolyticum is made from a mixture of proteins derived from a certain bacteria.

Collagenase clostridium histolyticum is used to treat Dupuytren's contracture in adults. This condition causes an abnormal thickening of the tissue in the palm of the hand. This condition may get worse over time and form a "cord" in your palm, causing a permanent bend in your finger.

Collagenase clostridium histolyticum may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before receiving collagenase clostridium histolyticum?

Multum donot

You should not use this medication if you are allergic to it.

To make sure you can safely receive this medication, tell your doctor if you have a bleeding or blood clotting disorder, such as hemophilia.

FDA pregnancy category B. Collagenase clostridium histolyticum is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Multum nobrfeed

It is not known whether collagenase clostridium histolyticum passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is collagenase clostridium histolyticum given?

This medication is injected directly into the "cord" of the affected hand. A healthcare provider will give you this injection.

Multum donot

After your injection, do not touch or put pressure on the treated area of the hand for the rest of the day. Keep the treated hand elevated until bedtime.

The day after your injection, your doctor will need to examine your hand to see if your condition has improved. If you still have the cord, your doctor may try to break it by extending your treated finger.

Collagenase clostridium histolyticum is usually given once every 4 weeks and you may receive more than one injection at a time. Follow your doctor's dosing instructions very carefully.

You may need to wear a splint on your hand for a short time to keep your fingers straight, especially at night. You may also need to perform daily finger exercises. Follow your doctor's instructions.

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Call your doctor if you have trouble bending the treated finger after the swelling goes down.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your collagenase clostridium histolyticum injection.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Overdose symptoms may include some of the serious side effects listed in this medication guide.

What should I avoid before and after receiving collagenase clostridium histolyticum?

Multum donot

Until you visit your doctor the day after your injection, do not flex or extend the fingers of your treated hand. Doing so may cause the medicine to spread away from the treatment area, making it less effective.

Avoid any strenuous activity using the treated hand until your doctor tells you to resume normal activities.

What are the possible side effects of collagenase clostridium histolyticum?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Tell your caregiver at once if you have a serious side effect such as:

  • feeling like you might pass out (even while lying down);
  • bruising or bleeding in the treated hand;
  • severe pain, itching, redness, warmth, swelling, or other irritation in the treated hand;
  • numbness or tingling in the treated hand;
  • fever, chills, body aches, flu symptoms, swollen glands;
  • swollen glands in your elbow or underarm; or
  • sudden pain, snapping or popping sound, bruising, loss of movement, or swelling in the joints of your hand.

Less serious side effects may include:

  • mild pain or tenderness in the treated hand;
  • cracked skin; or
  • underarm pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs can affect collagenase clostridium histolyticum?

Before you receive this medication, tell your doctor about all other medicines you have used within the past 7 days, especially medication used to prevent blood clots, such as:

  • high doses of aspirin (more than 150 milligrams per day);
  • a blood thinner such as warfarin (Coumadin);
  • argatroban (Acova), bivalirudin (Angiomax), lepirudin (Refludan);
  • dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra); or
  • abciximab (ReoPro), anagrelide (Agrylin), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), eptifibatide (Integrelin), prasugrel (Effient), ticlopidine (Ticlid), tirofiban (Aggrastat).

This list is not complete and other drugs may interact with collagenase clostridium histolyticum. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about collagenase clostridium histolyticum.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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