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esomeprazole

Pronunciation: ee so MEP ra zol

Brand: NexIUM

Nexium 20 mg

capsule, purple, imprinted with NEXIUM, 20 mg

Image of Nexium 20 mg
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Nexium 40 mg

capsule, purple, imprinted with NEXIUM, 40 mg

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What is the most important information I should know about esomeprazole?

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.

Multum donot

You should not take this medication if you are allergic to esomeprazole or to any other benzimidazole medication such as albendazole (Albenza), or mebendazole (Vermox).

Before you take esomeprazole, tell your doctor if you have severe liver disease or low levels of magnesium in your blood.

Multum donot

Esomeprazole is not for immediate relief of heartburn symptoms.

Some conditions are treated with a combination of esomeprazole and antibiotics. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

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Take this medication for the full prescribed length of time. Your symptoms may improve before the condition is fully treated.

What is esomeprazole?

Esomeprazole is in a group of drugs called proton pump inhibitors. Esomeprazole decreases the amount of acid produced in the stomach.

Esomeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Esomeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

Esomeprazole may also be given to prevent gastric ulcer caused by infection with helicobacter pylori (H. pylori), or by the use of nonsteroidal anti-inflammatory drugs (NSAIDs).

Multum donot

Esomeprazole is not for immediate relief of heartburn symptoms.

Esomeprazole may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking esomeprazole?

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.

Multum donot

You should not take this medication if you are allergic to esomeprazole or to any other benzimidazole medication such as albendazole (Albenza), or mebendazole (Vermox).

To make sure you can safely take esomeprazole, tell your doctor if you have any of these other conditions:

  • severe liver disease; or
  • low levels of magnesium in your blood.
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Taking a proton pump inhibitor such as esomeprazole may increase your risk of bone fracture in the hip, wrist, or spine. This effect has occurred mostly in people who have taken the medication long term or at high doses, and in those who are age 50 and older. It is not clear whether esomeprazole is the actual cause of an increased risk of fracture. Before you take this medication, tell your doctor if you have osteoporosis or osteopenia (low bone mineral density).

Some conditions are treated with a combination of esomeprazole and antibiotics. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

FDA pregnancy category B. Esomeprazole is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

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It is not known whether esomeprazole passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take esomeprazole?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

This medicine is usually given for 4 to 8 weeks only. Your doctor may recommend a second course of treatment if you need additional healing time.

Multum water

Take each dose with a full glass (8 ounces) of water.

Multum stomach

Esomeprazole should be taken at least one hour before a meal.

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Do not crush, chew, break, or open a delayed-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

You may open the delayed-release capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow this mixture right away without chewing. Do not save the mixture for later use. Discard the empty capsule.

Esomeprazole can be given through a nasogastric (NG) feeding tube. Open the capsule and sprinkle the medicine into a 60-milliliter syringe. Mix in 50 milliliters of water. Place the plunger into the syringe and shake the mixture well. Make sure there are no medicine granules stuck in the tip of the syringe. Attach the syringe to the NG tube and push the plunger down to empty the syringe into the tube. Then flush the tube with more water to wash the contents down.

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Take this medication for the full prescribed length of time. Your symptoms may improve before the condition is fully treated.

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Call your doctor if your symptoms do not improve or if they get worse while you are taking this medicine.

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This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using esomeprazole.

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Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include confusion, headache, drowsiness, blurred vision, fast heartbeat, nausea, dry mouth, sweating, flushing, shortness of breath, tremor, loss of coordination, or seizure (convulsions).

What should I avoid while taking esomeprazole?

This medication can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking esomeprazole and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

What are the possible side effects of esomeprazole?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using esomeprazole and call your doctor at once if you have symptoms of low magnesium such as:

  • dizziness, confusion;
  • fast or uneven heart rate;
  • jerking muscle movements;
  • jittery feeling;
  • diarrhea that is watery or bloody;
  • muscle cramps, muscle weakness or limp feeling;
  • cough or choking feeling; or
  • seizure (convulsions).

Less serious side effects may include:

  • headache, drowsiness;
  • mild diarrhea;
  • nausea, stomach pain, gas, constipation; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect esomeprazole?

Multum donot

Esomeprazole should not be taken together with atazanavir (Reyataz) or nelfinavir (Viracept). Tell your doctor if you are taking either of these medications to treat HIV or AIDS.

Tell your doctor about all other medicines you use, especially:

  • cilostazol (Pletal);
  • citalopram (Celexa);
  • clopidogrel (Plavix);
  • dexamethasone (Cortastat, Dexasone, Solurex, DexPak);
  • diazepam (Valium);
  • digoxin (Lanoxin, Lanoxicaps);
  • methotrexate (Rheumatrex, Trexall);
  • rifampin (Rifadin, Rifater, Rifamate);
  • St. John's wort;
  • tacrolimus (Prograf);
  • voriconazole (Vfend); or
  • HIV/AIDS medication such as etravirine (Intelence), rilpivirine (Complera, Edurant), or saquinavir (Invirase).

This list is not complete and other drugs may interact with esomeprazole. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about esomeprazole.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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