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  • acetaminophen, dextromethorphan, pseudoephedrine, and pyrilamine
 

acetaminophen, dextromethorphan, pseudoephedrine, and pyrilamine

Pronunciation: a SEET a MIN oh fen, pir IL a meen, DEX troe meth OR fan, SOO doe e FED rin

Brand: Robitussin Night Relief

What is the most important information I should know about this medicine?

Multum donot

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day.

Multum emt

You should not use this medicine if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate.

Multum donot

Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid.

Multum donot

Do not use this medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Multum noalcohol

Avoid drinking alcohol. It may increase your risk of liver damage while you are taking acetaminophen, and can increase certain side effects of pyrilamine.

Multum emt

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

What is acetaminophen, dextromethorphan, pseudoephedrine, and pyrilamine?

Acetaminophen is a pain reliever and fever reducer.

Dextromethorphan is a cough suppressant. It affects the cough reflex in the brain that triggers coughing.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Pyrilamine is an antihistamine that reduces the effects of the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

The combination of acetaminophen, dextromethorphan, pseudoephedrine, and pyrilamine is used to treat headache, fever, body aches, cough, runny nose, sneezing, itching, and watery eyes caused by allergies, the common cold, or the flu.

Multum smoking

This medicine will not treat a cough that is caused by smoking, asthma, or emphysema.

Acetaminophen, dextromethorphan, pseudoephedrine, and pyrilamine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking this medicine?

Multum emt

You should not use this medicine if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate.

Multum donot

Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid.

Multum donot

Do not use this medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

  • liver disease, cirrhosis, a history of alcoholism, or if you drink more than 3 alcoholic beverages per day;
  • a blockage in your digestive tract (stomach or intestines);
  • kidney disease;
  • cough with mucus, or cough caused by emphysema or chronic bronchitis;
  • enlarged prostate or urination problems; or
  • if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).
Multum nopreg

It is not known whether acetaminophen, dextromethorphan, pseudoephedrine, and pyrilamine will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.

Multum nobrfeed

Acetaminophen, dextromethorphan, pseudoephedrine, and pyrilamine may pass into breast milk and may harm a nursing baby. Antihistamines and decongestants may also slow breast milk production. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

How should I take this medicine?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. This medicine is usually taken only for a short time until your symptoms clear up.

Multum donot

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Multum nochild

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Measure liquid medicine with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.

Do not take for longer than 7 days in a row. Stop taking the medicine and call your doctor if you still have a fever after 3 days of use, you still have pain after 7 days (or 5 days if treating a child), if your symptoms get worse, or if you have a skin rash, ongoing headache, or any redness or swelling.

Multum emt

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.

Multum rt

Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze.

What happens if I miss a dose?

Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking this medicine?

Multum emt

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Multum noalcohol

Avoid drinking alcohol. It may increase your risk of liver damage while you are taking acetaminophen, and can increase certain side effects of pyrilamine.

Multum dizzy

This medicine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

What are the possible side effects of this medicine?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • chest pain, rapid pulse;
  • fast, slow, or uneven heart rate;
  • severe dizziness or anxiety, feeling like you might pass out;
  • severe headache;
  • mood changes, confusion, hallucinations, severe nervousness;
  • tremor, seizure (convulsions);
  • fever, easy bruising or bleeding, unusual weakness;
  • urinating less than usual or not at all;
  • nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes); or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, uneven heartbeats, seizure).

Less serious side effects may include:

  • dizziness, drowsiness, mild headache;
  • dry mouth, nose, or throat;
  • constipation, diarrhea, mild nausea, upset stomach;
  • blurred vision;
  • feeling restless or irritable; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect this medicine?

Multum dizzy

Ask a doctor or pharmacist before using this medicine if you regularly use other medicines that make you sleepy (such as narcotic pain medication, sedatives, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by pyrilamine.

Ask a doctor or pharmacist if it is safe for you to use acetaminophen, dextromethorphan, pseudoephedrine, and pyrilamine if you are also using any of the following drugs:

  • leflunomide (Arava);
  • topiramate (Topamax);
  • zonisamide (Zonegran);
  • an antibiotic, antifungal medicine, sulfa drug, or tuberculosis medicine;
  • an antidepressant;
  • birth control pills or hormone replacement therapy;
  • bladder or urinary medications;
  • blood pressure medication;
  • a bronchodilator;
  • cancer medicine;
  • cholesterol-lowering medications such as Lipitor, Niaspan, Zocor, Vytorin, and others;
  • gout or arthritis medications (including gold injections);
  • HIV/AIDS medication;
  • medication for nausea and vomiting, stomach ulcers, or irritable bowel syndrome;
  • medicines to treat psychiatric disorders;
  • an NSAID such as Advil, Aleve, Arthrotec, Cataflam, Celebrex, Indocin, Motrin, Naprosyn, Treximet, Voltaren, others; or
  • seizure medication.

This list is not complete and there may be other drugs that can affect acetaminophen, dextromethorphan, pseudoephedrine, and pyrilamine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about acetaminophen, dextromethorphan, pseudoephedrine, and pyrilamine .


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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