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  • tamoxifen
 

tamoxifen

Pronunciation: ta MOX i fen

Brand: Soltamox

Nolvadex 10 mg

round, white, imprinted with NOLVADEX 600, LOGO

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Tamoxifen 10 mg-BAR

round, white, imprinted with barr, 446

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Tamoxifen 10 mg-MYL

round, white, imprinted with M, 144

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Tamoxifen 10 mg-TEV

round, white, imprinted with 93 784

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Tamoxifen 20 mg-BAR

round, white, imprinted with barr, 904

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Tamoxifen 20 mg-MYL

round, white, imprinted with M, 274

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Tamoxifen 20 mg-TEV

round, white, imprinted with 93 782

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What is the most important information I should know about tamoxifen?

Multum nopreg

Do not use tamoxifen if you are pregnant. It could harm the unborn baby. Use a barrier form of birth control (such as a condom or diaphragm with spermicide) while you are using this medication and for at least 2 months after your treatment ends.

Multum donot

You should not use tamoxifen if you are allergic to it, or if you have a history of blood clots in your veins or your lungs, or if you are also taking a blood thinner such as warfarin (Coumadin).

Before using tamoxifen, tell your doctor if you have liver disease, high triglycerides (a type of fat in the blood), a history of cataract, or a history of stroke or blood clot. Also tell your doctor if you if you are receiving chemotherapy or radiation treatment.

If you are taking tamoxifen to reduce your risk of breast cancer, you may need to take your first dose while you are having a menstrual period. You may also need to have a pregnancy test before you start taking tamoxifen, to make sure you are not pregnant. Follow your doctor's instructions.

Multum emt

Taking tamoxifen may increase your risk of uterine cancer, stroke, or a blood clot in the lung, which can be fatal. Talk with your doctor about your specific risks in taking this medication.

To make sure this medication is not causing harmful effects, your doctor may want you to have mammograms and to perform routine breast self exams on a regular basis. Your liver function may also need to be tested. Visit your doctor regularly.

What is tamoxifen?

Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow.

Tamoxifen is used to treat some types of breast cancer in men and women. Tamoxifen is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer).

Tamoxifen may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking tamoxifen?

Multum donot

You should not use tamoxifen if you are allergic to it, or if you have:

  • a history of blood clots in your veins or your lungs; or
  • if you are also taking a blood thinner such as warfarin (Coumadin).

To make sure you can safely take tamoxifen, tell your doctor if you have any of these other conditions:

  • liver disease;
  • high cholesterol or triglycerides (a type of fat in the blood);
  • a history of stroke or blood clot;
  • a history of cataract; or
  • if you are receiving chemotherapy or radiation.
Multum emt

Taking tamoxifen may increase your risk of uterine cancer, stroke, or a blood clot in the lung, which can be fatal. Talk with your doctor about your specific risks in taking this medication.

Multum nopreg

FDA pregnancy category D. Do not use tamoxifen if you are pregnant. It could harm the unborn baby. Use a barrier form of birth control (such as a condom or diaphragm with spermicide) while you are using this medication and for at least 2 months after your treatment ends.

Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment.

Multum nobrfeed

It is not known whether tamoxifen passes into breast milk or if it could harm a nursing baby. However, this medication may slow breast milk production. You should not breast-feed while taking tamoxifen.

How should I take tamoxifen?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Multum water

Take this medication with a full glass (8 ounces) of water.

Tamoxifen can be taken with or without food.

Multum nopreg

If you are taking tamoxifen to reduce your risk of breast cancer, you may need to take your first dose while you are having a menstrual period. You may also need to have a pregnancy test before you start taking tamoxifen, to make sure you are not pregnant. Follow your doctor's instructions.

Use tamoxifen regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. You may need to keep using this medication for up to 5 years.

To make sure this medication is not causing harmful effects, your doctor may want you to have mammograms and to perform routine breast self exams on a regular basis. Your liver function may also need to be tested. Visit your doctor regularly.

Multum rt

Store at room temperature away from moisture, heat, or cold. Do not freeze.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking tamoxifen?

Avoid eating soy or soy products without first asking your doctor.

What are the possible side effects of tamoxifen?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using tamoxifen and call your doctor at once if you have a serious side effect such as:

  • sudden numbness or weakness, especially on one side of the body;
  • sudden severe headache, confusion, problems with vision, speech, or balance;
  • chest pain, sudden cough, wheezing, rapid breathing, fast heart rate;
  • pain, swelling, warmth, or redness in one or both legs;
  • nausea, loss of appetite, increased thirst, muscle weakness, confusion, and feeling tired or restless;
  • unusual vaginal bleeding or discharge;
  • irregular menstrual periods;
  • pain or pressure in your pelvic area;
  • blurred vision, eye pain, or seeing halos around lights;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • fever, chills, body aches, flu symptoms;
  • new breast lump; or
  • upper stomach pain, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • hot flashes;
  • bone pain, joint pain, or tumor pain;
  • swelling in your hands or feet;
  • vaginal itching or dryness;
  • decreased sex drive, impotence, or difficulty having an orgasm;
  • headache, dizziness, depression; or
  • thinning hair.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect tamoxifen?

Many drugs can interact with tamoxifen. Below is just partial list. Tell your doctor if you are using any of these medications:

  • bromocriptine (Parlodel);
  • cimetidine (Tagamet);
  • clozapine (Clozaril, FazaClo);
  • cyclophosphamide (Cytoxan, Neosar);
  • isoniazid (for treating tuberculosis);
  • letrozole (Femara);
  • methimazole (Tapazole);
  • nicardipine (Cardene);
  • pioglitazone (Actos);
  • rifampin (Rifadin, Rifater, Rifamate, Rimactane);
  • ropinirole (Requip);
  • ticlopidine (Ticlid);
  • tranylcypromine (Parnate);
  • anti-malaria medication such as chloroquine (Arelan) or pyrimethamine (Daraprim), or quinine (Qualaquin);
  • an antibiotic such as terbinafine (Lamisil);
  • an antidepressant such as bupropion (Wellbutrin, Zyban), clomipramine (Anafranil), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine (Prozac), imipramine (Tofranil), paroxetine (Paxil), sertraline (Zoloft), or tranylcypromine (Parnate);
  • a heart rhythm medication such as amiodarone (Cordarone, Pacerone) or quinidine (Quin-G);
  • HIV or AIDS medicine such as delavirdine (Rescriptor) or ritonavir (Norvir); or
  • medicine to treat psychiatric disorders, such as aripiprazole (Abilify), chlorpromazine (Thorazine), fluphenazine (Permitil, Prolixin), haloperidol (Haldol), perphenazine (Trilafon), or thioridazine (Mellaril).

This list is not complete and other drugs may interact with tamoxifen. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about tamoxifen.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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