Pentalogy of Cantrell

National Organization for Rare Disorders, Inc.

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It is possible that the main title of the report Pentalogy of Cantrell is not the name you expected.

Disorder Subdivisions

  • None

General Discussion

Pentalogy of Cantrell is a rare disorder that is present at birth (congenital). Pentalogy of Cantrell is characterized by a combination of birth defects. These birth defects can potentially involve the breastbone (sternum), the muscle that separates the chest cavity from the abdomen and aids in breathing (diaphragm), the thin membrane that lines the heart (pericardium), the abdominal wall, and the heart. Pentalogy of Cantrell occurs with varying degrees of severity, potentially causing severe, life-threatening complications. Most infants do not develop all of the potential defects, which may be referred to as incomplete pentalogy of Cantrell. When all five defects are present, this is referred to as complete pentalogy of Cantrell. The variability of the disorder from one individual to another can be significant. The exact cause of pentalogy of Cantrell is unknown. Most cases are believed to occur sporadically.

Supporting Organizations

Birth Defect Research for Children, Inc.

976 Lake Baldwin Lane
Orlando, FL 32814
Tel: (407)895-0802

CHERUBS - The Association of Congenital Diaphragmatic Hernia Research, Awareness and Support

3650 Rogers Road, #290
Wake Forest, NC 27587
Tel: (919)610-0129
Fax: (815)425-9155
Tel: (855)234-2229

Congenital Heart Information Network (C.H.I.N.)

P.O. Box 3397
Margate City, NJ 08402-0397
Tel: (609)823-4507
Fax: (609)822-1574

Genetic and Rare Diseases (GARD) Information Center

PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311

Kids With Heart ~ National Association for Children's Heart Disorders, Inc.

1578 Careful Dr.
Green Bay, WI 54304
Tel: (920)498-0058
Fax: (920)498-0058
Tel: (800)538-5390

March of Dimes

1275 Mamaroneck Avenue
White Plains, NY 10605
Tel: (914)997-4488
Fax: (914)997-4763
Email: or
Website: and

NIH/National Institute of Child Health and Human Development

31 Center Dr
Building 31, Room 2A32
Bethesda, MD 20892
Fax: (866)760-5947
Tel: (800)370-2943

Real Hope for CDH Foundation

1171 Vermilion Road
Vermilion, OH 41089
Tel: (216)533-4476

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

Last Updated:  1/28/2014
Copyright  2014 National Organization for Rare Disorders, Inc.